Regulatory mechanisms for intracellular Ca2+ signaling and fluid secretion in rat parotid acinar cells
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چکیده
منابع مشابه
Hydrogen sulfide: a novel gaseous signaling molecule and intracellular Ca2+ regulator in rat parotid acinar cells.
In addition to nitric oxide (NO), hydrogen sulfide (H2S) is recognized as a crucial gaseous messenger that exerts many biological actions in various tissues. An attempt was made to assess the roles and underlying mechanisms of both gases in isolated rat parotid acinar cells. Ductal cells and some acinar cells were found to express NO and H2S synthases. Cevimeline, a muscarinic receptor agonist ...
متن کاملRat Parotid Acinar Cells
We used the pH-sensitive fluorescent dye 2',7'-bis(2-carboxyethyl)-5(6')-carboxyfluorescein to monitor the recovery of the intracellular pH (pH,) of rat parotid acini from an NH+-induced alkaline load. This recovery was markedly inhibited by the loop diuretic bumetanide and by Clremoval, indicating that it is largely due to NH' entry via the basolateral Na'-K+2Clcotransporter. The rate of recov...
متن کاملRyanodine receptor expression is associated with intracellular Ca2+ release in rat parotid acinar cells.
The ryanodine receptor mediates intracellular Ca2+ mobilization in muscle and nerve, but its physiological role in nonexcitable cells is less well defined. Like adenosine 3',5'-cyclic monophosphate and inositol 1,4,5-trisphosphate, cyclic ADP-ribose (0.3-5 μM) and ADP (1-25 μM) produced a concentration-dependent rise in cytosolic Ca2+ in permeabilized rat parotid acinar cells. Adenosine and AMP...
متن کاملHydrogen sulfide: a novel gaseous signaling molecule and intracellular Ca regulator in rat parotid acinar cells
Moustafa A, Habara Y. Hydrogen sulfide: a novel gaseous signaling molecule and intracellular Ca regulator in rat parotid acinar cells. Am J Physiol Cell Physiol 309: C480–C490, 2015. First published July 29, 2015; doi:10.1152/ajpcell.00147.2015.—In addition to nitric oxide (NO), hydrogen sulfide (H2S) is recognized as a crucial gaseous messenger that exerts many biological actions in various ti...
متن کاملMechanisms of Ca2+-stimulated fluid secretion by porcine bronchial submucosal gland serous acinar cells.
The serous acini of airway submucosal glands are important for fluid secretion in the lung. Serous cells are also sites of expression of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel. However, the mechanisms of serous cell fluid secretion remain poorly defined. In this study, serous acinar cells were isolated from porcine bronchi and studied using optical techniqu...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1999
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)34078-8